Enzymatic C-demethylation of 1-[2-(5-tert-butyl-[1,3,4] oxadiazole-2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133) in rat liver microsomes.

Enzymatic C-demethylation of 1-[2-(5-tert-butyl-[1, 3, 4] Oxadiazole-2-carbonyl)-4-fluoro-pyrrolidin-1- Yl]-2-(2-hydroxy-1, 1-dimethyl-ethylamino)- Ethanone in Rat Liver Microsomes

Short Communication Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole- 2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl- ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes

The in vitro metabolism of 1-[2-(5-tert-butyl-[1,3,4] oxadiazole-2carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133), a novel dipeptidyl peptidase-4 inhibitor, was investigated using a hepatic microsomal system. The structures of the metabolites were characterized using mass spectral analysis and by comparison with synthetic references. The in vitro i...

Short Communication Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole- 2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl- ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes

The in vitro metabolism of 1-[2-(5-tert-butyl-[1,3,4] oxadiazole-2carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133), a novel dipeptidyl peptidase-4 inhibitor, was investigated using a hepatic microsomal system. The structures of the metabolites were characterized using mass spectral analysis and by comparison with synthetic references. The in vitro i...

Short Communication Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole- 2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl- ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes

The in vitro metabolism of 1-[2-(5-tert-butyl-[1,3,4] oxadiazole-2carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133), a novel dipeptidyl peptidase-4 inhibitor, was investigated using a hepatic microsomal system. The structures of the metabolites were characterized using mass spectral analysis and by comparison with synthetic references. The in vitro i...

Short Communication Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole- 2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl- ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes

The in vitro metabolism of 1-[2-(5-tert-butyl-[1,3,4] oxadiazole-2carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133), a novel dipeptidyl peptidase-4 inhibitor, was investigated using a hepatic microsomal system. The structures of the metabolites were characterized using mass spectral analysis and by comparison with synthetic references. The in vitro i...